Preoperative Cognitive Reserve and Brain Integrity Explains Variabilty During Anesthesia

Brain Burden and Cognitive Reserve

Read Full Scientific Article 


Our research team shows that baseline brain integrity (brain markers commonly seen with Alzheimer’s Disease-Vascular Dementia) and cognitive function predict variability during a controlled period of anesthesia while having knee replacement surgery. This is the first study to examine intra-individual variability on a common 2-channel EEG monitor used to assess depth of anesthesia.  Please see our full article (link above).

Figure shows case examples with predictor variables and 2-channel EEG output. The top two rows (case comparison example 1) presents two individuals in their 60’s electing TKA. The bottom two rows (case comparison example 2) presents two individuals in their 80’s electing TKA. The left column presents case demographics and final standardized scores for primary predictor variables of interest. The middle column depicts the brain variables of interest (entorhinal thickness in yellow; leukoaraiosis in teal; ventricle size in pink) and standardized brain integrity score. The right column shows the 2-channel EEG output and processed/derived EEG intraindividual variability score. Blue vertical lines indicate time of tourniquet inflation (left line) and tourniquet release (right line).