Verbal Memory in Parkinson’s Disease

Please read about our recent 2015 paper discussing temporal lobe and frontal-subcortical contributions to verbal memory impairment in Parkinson’s Disease.

For this investigation, Dr. Tanner and his colleagues examined verbal memory in idiopathic Parkinson’s disease (PD) and the significance of the left entorhinal cortex and left entorhinal-retrosplenial region connections on memory impairment in Parkinson’s disease.  The findings demonstrate that only white matter connections associated with the entorhinal cortex significantly contributed to memroy performance in the sample.  There was no contribution from the subcortical gray matter structures typically associated with the Parkinson’s disease illness.  The findings address the significance of white matter on cognition in Parkinson’s disease.  It also addresses the source of memory difficulties in Parkinson’ s disease.

The full article can be found at: Temporal Lobe and Memory

Acknowledgements: This work is based in part on Dr. Jared Tanners dissertation, which was completed in partial fulfillment of his Doctor of Philosophy Degree in the Department of Clinical and Health Psychology,University of Florida, Gainesville, Florida. We are most grateful for the participants and their time. We thank Nadine Schwab, M.S., Peter Nguyen, M.S., Jade Ward, B.S., and Sandra Mitchell, Ph.D., for their assistance with data collection and study support. We thank the Center for Movement Disorder and Neurorestoration physicians and nurse practitioners/ physician assistants for their referrals to our research investigation. We are thankful to the reviewers and the associate editor for their constructive comments. Fiber tracking images rendered using TrackVis (Ruopeng Wang, Van J. Wedeen,, Martinos Center for Biomedical Imaging, Massachusetts General Hospital). Study Funding: Supported by National Institute for Neurological Disorders and Stroke (NINDS) K23NS60660, NINDS RO1NS082386-02, and in part by the Center for Movement Disorders and Neurorestoration, as well as the National Institutes of Health/National Center for Advancing Translational Sciences (NIH/NCATS) Clinical and Translational Science Award to the University of Florida UL1TR000064. Drs. Tanner, Mareci, Okun, Bowers, and Price report grants from National Institutes of Health (K23NS60660 (CP), R01NR014810 (CP), RO1NS082386 (CP)) during the conduct of the study. Dr. Libon has no conflicts of interest to declare.